Extraskeletal Osteosarcoma. Case Report

Keywords: Extraskeletal osteosarcoma, soft-tissue sarcoma

Abstract

Extraskeletal osteosarcoma (EOS) is a high-grade malignant tumor that accounts for less than 2% of soft tissue sarcomas and mainly engages people between the fifth and sixth decade of life. It is typically of late diagnosis, with an extensive symptomdiagnosis period greater than 6 months compared to conventional osteosarcoma. We report the case of a 43-year-old patient who presented in our service with a 1-year-old tumor localized in the gluteal and left thigh region. After inconclusive paraclinical studies and biopsy, the tumor was surgically resected with wide margins and diagnosed as EOS after the histological analysis of the piece. The patient showed a very good clinical and paraclinical progression without signs of local or distant recurrence after 20 months of follow-up.

Downloads

Download data is not yet available.

Author Biographies

Juan Miguel Del Castillo Bellón, Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay
Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay
Santiago Pache, Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay
Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay
Claudio Silveri, Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay
Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay
Nicolás Casales, Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay
Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay
Alejandro Cúneo, Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay
Traumatology and Orthopedics Clinic, Universidad de la República, Montevideo, Uruguay

References

Jo VY, Fletcher CDM. WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition.

Pathology 2014;46(2):95-104. https://doi.org/10.1097/PAT.0000000000000050

Lee JS, Fetsch JF, Wasdhal DA, Lee BP, Pritchard DJ, Nascimento AG. A review of 40 patients with extraskeletal

osteosarcoma. Cancer 1995;76(11):2253-9. https://doi.org/10.1002/1097-0142(19951201)76:11<2253::aid-cncr2820761112>3.0.co;2-8

Lidang Jensen M, Schumacher B, Myhre Jensen O, Steen Nielsen O, Keller J. Extraskeletal osteosarcomas: a

clinicopathologic study of 25 cases. Am J Surg Pathol 1998;22(5):588-94. https://doi.org/10.1097/00000478-199805000-00010

McCarter MD, Lewis JJ, Antonescu CR, Brennan MF. Extraskeletal osteosarcoma: analysis of outcome of a rare

neoplasm. Sarcoma 2000;4(3):119-23. https://doi.org/10.1080/13577140020008084

Sordillo PP, Hajdu SI, Magill GB, Golbey RB. Extraosseous osteogenic sarcoma. A review of 48 patients. Cancer

;51(4):727-34. https://doi.org/10.1002/1097-0142(19830215)51:4<727::AID-CNCR2820510429>3.0.CO;2-I

Wilson H. Extraskeletal ossifying tumors. Ann Surg 1941;113(1):95-112. https://doi.org/10.1097/00000658-194101000-00013

Mc Auley G, Jagannathan J, O’Regan K, Krajewski KM, Hornick JL, Butrynskiet J, et al. Extraskeletal

osteosarcoma: Spectrum of imaging findings. Am J Roentgenol 2012;198(1):31-7. https://doi.org/10.2214/AJR.11.6927

Torigoe T, Yazawa Y, Takagi T, Terakado A, Kurosawa H. Extraskeletal osteosarcoma in Japan: multiinstitutional

study of 20 patients from the Japanese Musculoskeletal Oncology Group. J Orthop Sci 2007;12(5):424-9. https://doi.org/10.1007/s00776-007-1164-8

Campanacci M. Bone and soft tissue tumors. Vienna: Springer; 1999.

Shanoff LB, Spira M, Hardy SB. Myositis ossificans: evolution to osteogenic sarcoma. Report of a histologically

verified case. Am J Surg 1967;113(4):537-41. https://doi.org/10.1016/0002-9610(67)90203-6

Bacci G, Ferrari S, Longhi A, Mellano D, Giacomini S, Forni C. Delay in diagnosis of high-grade osteosarcoma of the extremities. Has it any effect on the stage of disease? Tumori 2000;86(3):204-6. https://doi.org/10.1177/030089160008600305

Longhi A, Bielack SS, Grimer R, Whelan J, Windhager R, Leithneret A, et al. Extraskeletal osteosarcoma: A

European Musculoskeletal Oncology Society study on 266 patients. Eur J Cancer 2017;74:9-16. https://doi.org/10.1016/j.ejca.2016.12.016

Choi LE, Healey JH, Kuk D, Brennan MF. Analysis of Outcomes in extraskeletal osteosarcoma: a review of fiftythree cases. J Bone Joint Surg Am 2014;96(1):e2-1-8. https://doi.org/10.2106/JBJS.M.00339

Bane BL, Evans HL, Ro JY, Carrasco CH, Grignon DJ, Benjamin RS, et al. Extraskeletal osteosarcoma. A

clinicopathologic review of 26 cases. Cancer 1990;65(12):2762-70. https://doi.org/10.1002/1097-0142(19900615)65:12<2762::aid-cncr2820651226>3.0.co;2-k

Varma DG, Ayala AG, Guo SQ, Moulopoulos LA, Kim EE, Charnsangavej C. MRI of extraskeletal osteosarcoma. J

Comput Assist Tomogr 1993;17(3):414-7. https://doi.org/10.1097/00004728-199305000-00015

Lee S, Lee MR, Lee SJ, Kyung Ahn H, Yi J, Yoon Yi S, et al. Extraosseous osteosarcoma: single institutional

experience in Korea. Asia Pac J Clin Oncol 2010;6(2):126-9. https://doi.org/10.1111/j.1743-7563.2010.01278.x

Goldstein-Jackson SY, Gosheger G, Delling G, Berdel WE, Ulrich Exner G, Jundt G, et al. Extraskeletal osteosarcoma has a favourable prognosis when treated like conventional osteosarcoma. J Cancer Res Clin Oncol

;131(8):520-6. https://doi.org/10.1007/s00432-005-0687-7

Published
2022-06-25
How to Cite
Del Castillo Bellón, J. M., Pache, S., Silveri, C., Casales, N., & Cúneo, A. (2022). Extraskeletal Osteosarcoma. Case Report. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 87(3), 371-377. https://doi.org/10.15417/issn.1852-7434.2022.87.3.1323
Section
Case Presentations