Extraskeletal Osteosarcoma. Case Report
Abstract
Extraskeletal osteosarcoma (EOS) is a high-grade malignant tumor that accounts for less than 2% of soft tissue sarcomas and mainly engages people between the fifth and sixth decade of life. It is typically of late diagnosis, with an extensive symptomdiagnosis period greater than 6 months compared to conventional osteosarcoma. We report the case of a 43-year-old patient who presented in our service with a 1-year-old tumor localized in the gluteal and left thigh region. After inconclusive paraclinical studies and biopsy, the tumor was surgically resected with wide margins and diagnosed as EOS after the histological analysis of the piece. The patient showed a very good clinical and paraclinical progression without signs of local or distant recurrence after 20 months of follow-up.Downloads
References
Jo VY, Fletcher CDM. WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition.
Pathology 2014;46(2):95-104. https://doi.org/10.1097/PAT.0000000000000050
Lee JS, Fetsch JF, Wasdhal DA, Lee BP, Pritchard DJ, Nascimento AG. A review of 40 patients with extraskeletal
osteosarcoma. Cancer 1995;76(11):2253-9. https://doi.org/10.1002/1097-0142(19951201)76:11<2253::aid-cncr2820761112>3.0.co;2-8
Lidang Jensen M, Schumacher B, Myhre Jensen O, Steen Nielsen O, Keller J. Extraskeletal osteosarcomas: a
clinicopathologic study of 25 cases. Am J Surg Pathol 1998;22(5):588-94. https://doi.org/10.1097/00000478-199805000-00010
McCarter MD, Lewis JJ, Antonescu CR, Brennan MF. Extraskeletal osteosarcoma: analysis of outcome of a rare
neoplasm. Sarcoma 2000;4(3):119-23. https://doi.org/10.1080/13577140020008084
Sordillo PP, Hajdu SI, Magill GB, Golbey RB. Extraosseous osteogenic sarcoma. A review of 48 patients. Cancer
;51(4):727-34. https://doi.org/10.1002/1097-0142(19830215)51:4<727::AID-CNCR2820510429>3.0.CO;2-I
Wilson H. Extraskeletal ossifying tumors. Ann Surg 1941;113(1):95-112. https://doi.org/10.1097/00000658-194101000-00013
Mc Auley G, Jagannathan J, O’Regan K, Krajewski KM, Hornick JL, Butrynskiet J, et al. Extraskeletal
osteosarcoma: Spectrum of imaging findings. Am J Roentgenol 2012;198(1):31-7. https://doi.org/10.2214/AJR.11.6927
Torigoe T, Yazawa Y, Takagi T, Terakado A, Kurosawa H. Extraskeletal osteosarcoma in Japan: multiinstitutional
study of 20 patients from the Japanese Musculoskeletal Oncology Group. J Orthop Sci 2007;12(5):424-9. https://doi.org/10.1007/s00776-007-1164-8
Campanacci M. Bone and soft tissue tumors. Vienna: Springer; 1999.
Shanoff LB, Spira M, Hardy SB. Myositis ossificans: evolution to osteogenic sarcoma. Report of a histologically
verified case. Am J Surg 1967;113(4):537-41. https://doi.org/10.1016/0002-9610(67)90203-6
Bacci G, Ferrari S, Longhi A, Mellano D, Giacomini S, Forni C. Delay in diagnosis of high-grade osteosarcoma of the extremities. Has it any effect on the stage of disease? Tumori 2000;86(3):204-6. https://doi.org/10.1177/030089160008600305
Longhi A, Bielack SS, Grimer R, Whelan J, Windhager R, Leithneret A, et al. Extraskeletal osteosarcoma: A
European Musculoskeletal Oncology Society study on 266 patients. Eur J Cancer 2017;74:9-16. https://doi.org/10.1016/j.ejca.2016.12.016
Choi LE, Healey JH, Kuk D, Brennan MF. Analysis of Outcomes in extraskeletal osteosarcoma: a review of fiftythree cases. J Bone Joint Surg Am 2014;96(1):e2-1-8. https://doi.org/10.2106/JBJS.M.00339
Bane BL, Evans HL, Ro JY, Carrasco CH, Grignon DJ, Benjamin RS, et al. Extraskeletal osteosarcoma. A
clinicopathologic review of 26 cases. Cancer 1990;65(12):2762-70. https://doi.org/10.1002/1097-0142(19900615)65:12<2762::aid-cncr2820651226>3.0.co;2-k
Varma DG, Ayala AG, Guo SQ, Moulopoulos LA, Kim EE, Charnsangavej C. MRI of extraskeletal osteosarcoma. J
Comput Assist Tomogr 1993;17(3):414-7. https://doi.org/10.1097/00004728-199305000-00015
Lee S, Lee MR, Lee SJ, Kyung Ahn H, Yi J, Yoon Yi S, et al. Extraosseous osteosarcoma: single institutional
experience in Korea. Asia Pac J Clin Oncol 2010;6(2):126-9. https://doi.org/10.1111/j.1743-7563.2010.01278.x
Goldstein-Jackson SY, Gosheger G, Delling G, Berdel WE, Ulrich Exner G, Jundt G, et al. Extraskeletal osteosarcoma has a favourable prognosis when treated like conventional osteosarcoma. J Cancer Res Clin Oncol
;131(8):520-6. https://doi.org/10.1007/s00432-005-0687-7
Manuscript acceptance by the Journal implies the simultaneous non-submission to any other journal or publishing house. The RAAOT is under the Licencia Creative Commnos Atribución-NoComercial-Compartir Obras Derivadas Igual 4.0 Internacional (CC-BY-NC.SA 4.0) (http://creativecommons.org/licences/by-nc-sa/4.0/deed.es). Articles can be shared, copied, distributed, modified, altered, transformed into a derivative work, executed and publicly communicated, provided a) the authors and the original publication (Journal, Publisher and URL) are mentioned, b) they are not used for commercial purposes, c) the same terms of the license are maintained.
In the event that the manuscript is approved for its next publication, the authors retain the copyright and will assign to the journal the rights of publication, edition, reproduction, distribution, exhibition and communication at a national and international level in the different databases. data, repositories and portals.
It is hereby stated that the mentioned manuscript has not been published and that it is not being printed in any other national or foreign journal.
The authors hereby accept the necessary modifications, suggested by the reviewers, in order to adapt the manuscript to the style and publication rules of this Journal.


