Non-osteoporotic Loss of Spinal Bone. Denosumab as a Therapeutic Tool and its Implications

Main Article Content

Pedro Luis Bazán
Alfredo Godoy Adaro
Gilmar Leonardo Hernández Molina
Richard Ángel Blanco Payano
Micalea Cinalli

Abstract

Background: Denosumab is a human monoclonal antibody that acts against RANKL, inhibiting bone destruction mediated by osteoclasts, thus avoiding bone loss. For this reason, it is used in the treatment of osteoporosis as an antiresorptive and is authorized for the treatment of giant cell tumor and multiple myeloma. Our objective is to understand its indications and contraindications for the treatment of non-osteoporotic bone loss.
Materials and Methods: A systematic review of English-language articles published between 2009 and 2023, using PRISMA criteria. Articles indicating or contraindicating the use of denosumab were considered forinclusion.
Results: From a total of 4306 articles, 18 articles were analyzed, which showed consensus on the dose and controls with tomography and indicated or contraindicated the use of denosumab.
Conclusions: Denosumab is recommended as a primary therapeutic option for unresectable spinal tumors, to prevent recurrences or to delay the formation of metastases from primary tumors or solid tumors, primarily breast, prostate, and lung, as well as for multiple myeloma spinal involvement. Denosumab iscurrently contraindicated in infectious lesions.

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How to Cite
Bazán, P. L., Godoy Adaro, A., Hernández Molina, G. L., Blanco Payano, R. Ángel, & Cinalli, M. (2024). Non-osteoporotic Loss of Spinal Bone. Denosumab as a Therapeutic Tool and its Implications. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 89(1), 83-89. https://doi.org/10.15417/issn.1852-7434.2024.89.1.1802
Section
Revisión Sistemática
Author Biographies

Pedro Luis Bazán, Spinal Pathology Unit, Orthopedics and Traumatology Service, Hospital Interzonal General de Agudos “General San Martín”, La Plata, Buenos Aires, Argentina

Spinal Pathology Unit, Orthopedics and Traumatology Service, Hospital Interzonal General de Agudos “General San Martín”, La Plata, Buenos Aires, Argentina

Alfredo Godoy Adaro, Spine Unit, Clínica Modelo S.A. Paraná, Entre Ríos, Argentina

Spine Unit, Clínica Modelo S.A. Paraná, Entre Ríos, Argentina

Gilmar Leonardo Hernández Molina, Spine Unit, Hospital Militar, Bogota, Colombia

Spine Unit, Hospital Militar, Bogota, Colombia

Richard Ángel Blanco Payano, Orthopedics and Traumatology Service, Hospital Regional de Loreto “Felipe Santiago Arriola Iglesias”, Iquitos, Peru

Orthopedics and Traumatology Service, Hospital Regional de Loreto “Felipe Santiago Arriola Iglesias”, Iquitos, Peru

Micalea Cinalli, Spinal Pathology Unit, Orthopedics and Traumatology Service, Hospital Interzonal General de Agudos “General San Martín”, La Plata, Buenos Aires, Argentina

Spinal Pathology Unit, Orthopedics and Traumatology Service, Hospital Interzonal General de Agudos “General San Martín”, La Plata, Buenos Aires, Argentina

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