Scaffold for bone tissue engineering: superficial modification with zinc. Preliminary study

  • Cristian Martínez Facultad de Odontologia- Universidad Nacional de Cuyo
  • Daniel Olmedo Facultad de Odontologia- Universidad de Buenos Aires
  • Andrés Ozols Facultad de Ingeniería - Universidad de Buenos Aires
DOI: https://doi.org/10.15417/264
Keywords: Tissue engineering, Hydroxyapatite, Scaffolds, Zinc

Abstract

The aim of this study is to develop a method of matrix synthesis for tissue engineering, capable of accelerating reparative processes and reducing the risk of infection, destined to reconstructive surgeries involving bone tissue. For this purpose the bovine bone mineral phase, hydroxyapatite, was used while retaining its dimensional structure. This is obtained from a chemical wash process followed by a thermal process that removes the entire organic components. This matrix is superficially modified with zinc oxide (ZnO), element known for its action in various biological processes and its antibacterial action. The procedure involves the intrusion of ZnO dispersions in alcohol solution-1,2,3-propanetriol, made in a thermal bath and the subsequent high temperature sintering. The degree of attachment and the Zn concentration on the hydroxyapatite matrix is determined by electron microscopy and energy spectrometry. X-ray diffraction shows that the incorporation of Zn ions in the surface forms Zn phosphates. The developed original process allows modifying in a simple way synthetic bone grafts, by providing antibacterial and osteoproliferative properties to the osteoconductive substrate.

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Author Biographies

Cristian Martínez, Facultad de Odontologia- Universidad Nacional de Cuyo
Especialista en  Cirugía Maxilofacial.Becario Doctoral de la Agencia Nacional de Promoción Científica y Tecnológica. Ministerio de Ciencia, Tecnología e Innovación Productiva (MinCyT).Becario de la Facultad de Odontología. Universidad Nacional de Cuyo. Argentina.Miembro del Grupo de Biomateriales para Prótesis* Facultad de Ingeniería. Universidad de Buenos Aires. Argentina.
Daniel Olmedo, Facultad de Odontologia- Universidad de Buenos Aires
Doctor en Odontología.  Facultad de Odontología. Universidad Nacional de Córdoba.Profesor Regular Adjunto con Dedicación Exclusiva. Cátedra de Anatomía Patológica. Facultad de Odontología. Universidad de Buenos Aires.Investigador Adjunto. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Especialista en Anatomía Patológica Bucal. Facultad de Odontología. Universidad de Buenos Aires.
Andrés Ozols, Facultad de Ingeniería - Universidad de Buenos Aires
Doctor en Ciencias Físicas. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires (F.C.E.y N.). Profesor Regular Adjunto con Dedicación Exclusiva de Física III-A. Investigador de la Universidad de Buenos Aires. Director del Grupo de Biomateriales para prótesis.* Facultad de Ingeniería. Universidad de Buenos Aires.Centro de innovación y desarrollo de Biomateriales de Riga (RBIAC). Universidad Tecnológica de Riga (Letonia, Comunidad Europea.

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Published
2013-09-30
How to Cite
Martínez, C., Olmedo, D., & Ozols, A. (2013). Scaffold for bone tissue engineering: superficial modification with zinc. Preliminary study. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 78(3), 138 - 143. https://doi.org/10.15417/264
Issue
Vol 78 No 3 (2013)
Section
Basic Research

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