Topical administration of tranexamic acid in primary total knee replacement.

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Published: Feb 15, 2018
DOI: https://doi.org/10.15417/697
Keywords:
tranexamic acid, total knee arthroplasty, blood transfusion

Main Article Content

Agustin Dauria
Clinica Depetris de Cadera y Rodilla
http://orcid.org/0000-0002-0741-1123
Hector Mario Depetris
Clinica Depetris de Cadera y Rodilla
http://orcid.org/0000-0001-7824-1355

Abstract

IntroductionTotal knee replacement is associated with extensive postoperative blood loss.Tranexamic acid is synthetic antifibrinolytic agent that, in the last few years, has been successfully used intravenously to reduce bleeding after total knee replacement. However, topical application of tranexamic acid in total knee replacement remains largely unexplored.MethodsWe conducted a retrospective study of 117 total knee primary replacements, where 63 of them received topical tranexamic acid, and the remaining 54 replacements in whom no tranexamic acid was used. A comparison analysis was made, capturing results of blood transfusion rates, postoperative hemoglobin levels (24 and 48 hs), number of changed bandages, associated comorbidities and complications.ResultsTranexamic acid reduced the blood tranfusion rate by 43.9% when compared with the group without tranexamic. We also found, that  the same group, resulted in a lower decline in postoperative hemoglobin levels (24 hs) by 2,12 gr/dl. There was no complications in both groups.ConclusionsTopically applied  tranexamic acid was effective in reducing the need for blood transfusion following total knee replacement, without additional adverse effects.

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How to Cite
Dauria, A., & Depetris, H. M. (2018). Topical administration of tranexamic acid in primary total knee replacement. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 83(1), 05-11. https://doi.org/10.15417/697
Issue
Vol 83 No 1 (2018)
Section
Clinical Research
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Author Biographies

Agustin Dauria, Clinica Depetris de Cadera y Rodilla

Medico Staff en Ortopedia y Traumatologia en Clinica Depetris

Hector Mario Depetris, Clinica Depetris de Cadera y Rodilla

Director Medico y Jefe de Servicio de Clinica Depetris de Cadera y Rodilla

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