Use of Denosumab in an Aneurysmal Bone Cyst of the Spine. Case Report and Literature Review

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Published: Dec 16, 2021
DOI: https://doi.org/10.15417/issn.1852-7434.2021.86.6.1121
Keywords:
Aneureysmal bone cyst, treatment, relapse, coadjuvant, denosumab

Main Article Content

Felipe Lanari Zubiaur
Grupo Médico Vertebral, Autonomous City of Buenos Aires, Argentina
https://orcid.org/0000-0003-4030-0959
Alfredo Osvaldo Godoy Adaro
Clínica Modelo S. A., Paraná, Entre Ríos, Argentina
https://orcid.org/0000-0001-8018-9197
Pedro Luis Bazán
Hospital Interzonal General de Agudos “General San Martín”, La Plata, Buenos Aires, Argentina
http://orcid.org/0000-0003-0060-6558

Abstract

Vertebral tumors of the spine have a very low frequency. The incidence of aneurysmal bone cyst (ABC) ranges between 1% and 4% of all tumors. Its predominant location is the lumbar spine, to a greater extent, in the posterior arch. According to published studies, this condition behaves aggressively, due to the root compression generated by its expansion. While there is literature on the surgical treatment of the tumor and its en bloc resection and embolization, there is no experience on the treatment with monoclonal antibodies. There are very few published articles that corroborate a treatment for recurrences or for inoperable or intralesional aneurysmal bone cysts, which leave the possibility open to other techniques. We present the case of a 38-year-old woman with lumbar pain radiating to the thigh. In studies, a tumor was detected, and the needle biopsy and imaging confirmed that it was an aneurysmal bone cyst. We planned the treatment with preoperative embolization and intracompartmental excision by subsequent surgery with the release of the dural sac. At six months, tumor recurrence was observed. Treatment with denosumab was indicated for two years, periodic controls were carried out and the remission of symptoms and improvement in the images were verified.

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How to Cite
Lanari Zubiaur, F., Godoy Adaro, A. O., & Bazán, P. L. (2021). Use of Denosumab in an Aneurysmal Bone Cyst of the Spine. Case Report and Literature Review. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 86(6), 821-828. https://doi.org/10.15417/issn.1852-7434.2021.86.6.1121
Issue
Vol 86 No 6 (2021)
Section
Case Presentations
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Author Biographies

Felipe Lanari Zubiaur, Grupo Médico Vertebral, Autonomous City of Buenos Aires, Argentina

Grupo Médico Vertebral, Autonomous City of Buenos Aires, Argentina

Alfredo Osvaldo Godoy Adaro, Clínica Modelo S. A., Paraná, Entre Ríos, Argentina

Clínica Modelo S. A., Paraná, Entre Ríos, Argentina

Pedro Luis Bazán, Hospital Interzonal General de Agudos “General San Martín”, La Plata, Buenos Aires, Argentina

Hospital Interzonal General de Agudos “General San Martín”, La Plata, Buenos Aires, Argentina

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