Limb and Trunk Lipoblastoma: Local Recurrence and Complications after Marginal Resection. A Multicenter Study
Abstract
Objectives: Lipoblastoma is a rare benign neoplasm that resembles white fat and can occur as a localized (lipoblastoma) or diffuse (lipoblastomatosis) tumor. Due to its rarity, the literature is mostly limited to case reports. The purpose of this study was to determine the local recurrence rate and complications after marginal resection of lipoblastomas located in the extremities or the back. Materials and Methods: We performed a multicenter retrospective review of the records of pediatric patients who had undergone surgical excision of lipoblastomas at 4 tertiary care institutions from 2008 to 2018. We recorded the demographic data, diagnostic method, the volume of the lesion, type of biopsy, complications, recurrence, and the need for additional procedures. Results: Throughout the study, 17 patients met the inclusion criteria for evaluation. The average patient age was 3.9 years, and 65% were male. The most common locations included thighs (N 9), low back region (N 2), and buttocks (N 2). The mean preoperative mass volume was 305.5 cm3 (range: 10.2 cm3 - 1745.8 cm3). The mean duration of follow-up was 2.8 years (range: 8 months to 5.6 years). One patient experienced recurrence (5.9%). One patient had a retracted skin scarring in the gluteal area. Conclusion: Marginal surgical resection of lipoblastomas located in the back or extremities showed a low recurrence rate at 2.8 years of follow-up and minimal complications.Downloads
References
Gilbert TJ, Goswitz JJ, Teynor JT, Griffiths HJ. Lipoblastoma of the foot. Skeletal Radiol 1996;25(3):283-6.
https:// doi.org/10.1007/s002560050081
Coffin CM, Lowichik A, Putnam A. Lipoblastoma (LPB): A clinicopathologic and immunohistochemical. Analysis
of 59 Cases. Am J Surg Pathol 2009;33(11):1705-12. https://doi.org/10.1097/PAS.0b013e3181b76462
Akhtar T, Alladi A, Ahmed SM, Siddappa OS. Giant lipoblastoma of the thigh: A rare soft tissue tumor in an infant. J Can Res Ther 2012;8:1578. https://doi.org/10.4103/0973-1482.95202
Jaffe RH. Recurrent lipomatous tumors of the groin: liposarcoma and lipoma pseudomyxomatodes. Arch Pathol 1926;1:381-7.
WHO Classification of Tumours Editorial Board. Soft Tissue and Bone Tumours. 5th ed., vol. 3. WHO Classification of Tumours Series, International Agency for Research on Cancer. Disponible en: https://publications.iarc.fr/588
Jung SM, Chang PY, Luo CC, Huang CS, Lai JY, Hsueh C. Lipoblastoma/lipoblastomatosis: a clinicopathologic
study of 16 cases in Taiwan. Pediatr Surg Int 2005;21(10):809-12. https://doi.org/10.1007/s00383-005-1502-x
Collins M, Chatten J. Lipoblastoma/lipoblastomatosis: A clinicopathologic study of 25 tumors. Am J Surg Pathol
;21(10):1131-7. https://doi.org/10.1097/00000478-199710000-00002
Kucera A, Šnajdauf J, Vyhnánek M, Morávek J, Kodet R, Stejskalová E, et al. Lipoblastoma in children: an analysis of 5 cases. Acta Chir Belg 2008;108(5):580-2. https://doi.org/10.1080/00015458.2008.11680289
Nam SH, Lim YJ, Kim YM. Inguinal lipoblastoma mimicking recurrent inguinal hernia. J Korean Assoc Pediatr
Surg 2014;20(2):5861. https://doi.org/10.13029/jkaps.2014.20.2.58.10
Armenise T, Gentile O, Orofino A, Leggio S, Lanzillotto PM, Paradies G, et al: Lipoblastoma in infant: Our experience. J Pediatr Surg Case Rep 2015;3(2):63–4. https://doi.org/10.1016/j.epsc.2014.12.001
Susam-Sen H, Yalcin B, Kutluk T, Tanyel FC, Haliloglu M, Akyuz C, et al. Lipoblastoma in children: Review of 12
cases. Pediatr Int 2017;59(5):545-50. https://doi.org/10.1111/ped.13239
Abdul-Ghafar J, Ahmad Z, Tariq MU, Kayani N, Uddin N. Lipoblastoma: a clinicopathologic review of 23 cases
from a major tertiary care center plus detailed review of literature. BMC Res Notes 2018;11(1):1-6.
https//doi.org/10.1186/s13104-018-3153-8
Shek KW, Cheng SS, Tse KS, Lai KC, Chan MK. Lipoblastoma: different features on magnetic resonance imaging. Hong Kong J Radiol 2015;18:302-6. https://doi.org/10.12809/hkjr1515332
Navarro OM. Pearls and pitfalls in the imaging of soft-tissue masses in children. Semin Ultrasound CT and MRI 2020;41(5):498-512. https://doi.org/10.1053/j.sult.2020.05.014
Moholkar S, Sebire NJ, Roebuck DJ. Radiological–pathological correlation in lipoblastoma and lipoblastomatosis. Pediatr Radiol 2006;36(8):851–6. https://doi.org/10.1007/s00247-006-0175-5
Ferreira J, Esteves G, Fonseca R, Martins C, André S, Lemos MM. Fine‐needle aspiration of lipoblastoma:
Cytological, molecular, and clinical features. Cancer Cytopathol 2017;125(12):934-9. https://doi.org/10.1002/cncy.21916
Agrawal P, Srinivasan R, Rajwanshi A, Gupta N, Dey P, Samujh R, et al. Fine needle aspiration cytology of
paediatric soft tissue tumours highlighting challenges in diagnosis of benign lesions and unusual malignant
tumours. Cytopathology 2019;30(3):301-8. https://doi.org/10.1111/cyt.12685
Kok KYY, Telisinghe PU. Lipoblastoma: clinical features, treatment, and outcome. World J Surg 2010;34(7):1517- 22. https://doi.org/10.1007/s00268-010-0466-8
Kerkeni Y, Sahnoun L, Ksia A, Hidouri S, Chahed J, Nouri A, et al. Lipoblastoma in childhood: About 10 cases. Afr J Paediatr Surg 2014;(11):32-4. https://doi.org/10.4103/0189-6725.129210
Ghosh P, Das RN, Ghosh R, Chatterjee U, Datta C, Mishra PK. Lipoblastoma and lipoblastomatosis: A
clinicopathological study of six cases. J Can Res Ther 2015;11(4):1040. https://doi.org/10.4103/0973-1482.176135
Morerio C, Nozza P, Tassano E, Rosanda C, Granata C, Panarello C, et al. Differential diagnosis of lipoma-like
lipoblastoma. Pediatr Blood Cancer 2009;52(1):132–4. https://doi.org/10.1002/pbc.21747
Krishnan J, Hathiramani V, Hastak M, Redkar RG. Myxoid lipoblastoma. Indian Pediatr 2013;50(6):603-5.
PMID: 23942405
Chung EB, Enzinger FM. Benign lipoblastomatosis: an analysis of 35 cases. Cancer 1973;32(2):482-92.
https://doi.org/10.1002/1097-0142(197308)32:23.0.co;2-e
Dao D, Najor AJ, Sun PY, Farrokhyar F, Moir CR, Ishitani MB. Follow-up outcomes of pediatric patients who
underwent surgical resection for lipoblastomas or lipoblastomatosis: a single-institution experience with a systematic review and meta-analysis. Pediatr Surg Int 2020;36(3):341-55. https://doi.org/10.1007/s00383-019-04612-z
Shen LY, Amin SM, Chamlin SL, Mancini AJ. Varied presentations of pediatric lipoblastoma: case series and review of the literature. Pediatr Dermatol 2017;34(2):180-6. https://doi.org/10.1111/pde.13071
Manuscript acceptance by the Journal implies the simultaneous non-submission to any other journal or publishing house. The RAAOT is under the Licencia Creative Commnos Atribución-NoComercial-Compartir Obras Derivadas Igual 4.0 Internacional (CC-BY-NC.SA 4.0) (http://creativecommons.org/licences/by-nc-sa/4.0/deed.es). Articles can be shared, copied, distributed, modified, altered, transformed into a derivative work, executed and publicly communicated, provided a) the authors and the original publication (Journal, Publisher and URL) are mentioned, b) they are not used for commercial purposes, c) the same terms of the license are maintained.
In the event that the manuscript is approved for its next publication, the authors retain the copyright and will assign to the journal the rights of publication, edition, reproduction, distribution, exhibition and communication at a national and international level in the different databases. data, repositories and portals.
It is hereby stated that the mentioned manuscript has not been published and that it is not being printed in any other national or foreign journal.
The authors hereby accept the necessary modifications, suggested by the reviewers, in order to adapt the manuscript to the style and publication rules of this Journal.
