Tibiotalocalcaneal Arthrodesis with Retrograde Intramedullary Nail in Patients with Charcot Neuroarthropathy of the Ankle and Hindfoot

Keywords: Charcot neuroarthropathy, ankle, hindfoot, diabetes mellitus, tibiotalocalcaneal arthrodesis, retrograde intramedullary nail

Abstract

Introduction: Tibiotalocalcaneal (TTC) arthrodesis is the treatment of choice for the surgical management of Charcot neuroarthropathy (CN) affecting the ankle. The primary goal is to avoid major amputation and restore a functional lower limb suitable for ambulation, thereby improving patients’ quality of life. Objective: To describe the clinical and radiological characteristics and evolution of patients with diabetes mellitus and Charcot neuroarthropathy who underwent TTC arthrodesis using a straight retrograde intramedullary compression nail. Materials and Methods: This retrospective case series included consecutive patients with CN of the ankle and hindfoot and diabetes mellitus who underwent TTC arthrodesis with a retrograde intramedullary nail. Radiographic union, complications, reoperations, limb salvage, and preoperative metabolic parameters (serum albumin and HbA1c) were evaluated. Results: Eight patients were included, with a median follow-up of 58 months (IQR 40.75–75.5). The median preoperative HbA1c was 6.6% (IQR 5.7–7), and the median serum albumin level was 3.41 g/dL (IQR 3.05–3.71). Three patients required revision surgery. Radiographic union was achieved in seven patients; two developed stable fibrous union, and one patient remains under follow-up.No patient required amputation. Conclusions: TTC arthrodesis with a retrograde intramedullary nail is a viable surgical option fordiabetic patients with Charcot neuroarthropathy involving the ankle. Optimizing preoperative metabolic status and comorbidities, along with appropriate management of osteomyelitis, is essential to reduce complications and promote bone healing.

Downloads

Download data is not yet available.

Author Biographies

Ana Cecilia Parise, Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Virginia María Cafruni, Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
N. Marina Carrasco, Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Julián Manuel Parma, Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Julieta Brué, Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Daniel Sebastián Villena, Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Leonardo Ángel Conti, Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Pablo Sotelano, Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
María Gala Santini Araujo, Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina
Foot and Ankle Medicine and Surgery Department, Hospital Italiano de Buenos Aires, Autonomous City of Buenos Aires, Argentina

References

La Fontaine J, Lavery L, Jude E. Current concepts of Charcot foot in diabetic patients. Foot (Edinb) 2016;26:7-14. https://doi.org/10.1016/j.foot.2015.11.001

Rosemberg DL, Sposeto RB, Godoy-Santos AL. Arthrodesis in the deformed Charcot foot. Foot Ankle Clin

;27(4):835-46. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1083751522000936

Ögüt T, Yontar NS. Surgical treatment options for the diabetic Charcot hindfoot and ankle deformity. Clin Podiatr Med Surg 2017;34(1):53-67. https://doi.org/10.1016/j.cpm.2016.07.007

Papa J, Myerson M, Girard P. Salvage, with arthrodesis, in intractable diabetic neuropathic arthropathy of the foot and ankle. J Bone Joint Surg 1993;75(7):1056. Disponible en:

https://journals.lww.com/jbjsjournal/abstract/1993/07000/salvage,_with_arthrodesis,_in_intractable_diabetic.12.aspx

Dalla Paola L, Volpe A, Varotto D, Postorino A, Brocco E, Senesi A, et al. Use of a retrograde nail for ankle

arthrodesis in Charcot neuroarthropathy: a limb salvage procedure. Foot Ankle Int 2007;28(9):967-70.

https://doi.org/10.3113/FAI.2007.0967

Brandão RA, Weber JS, Larson D, Prissel MA, Bull PE, Berlet GC, et al. New fixation methods for the treatment of the diabetic foot: Beaming, external fixation, and beyond. Clin Podiatr Med Surg 2018;35(1):63-76. https://doi.org/10.1016/j.cpm.2017.08.001

Ayoub MA. Ankle fractures in diabetic neuropathic arthropathy: can tibiotalar arthrodesis salvage the limb? J Bone Joint Surg Br 2008;90(7):906-14. https://doi.org/10.1302/0301-620X.90B7.20090

Trepman E, Nihal A, Pinzur MS. Current topics review: Charcot neuroarthropathy of the foot and ankle. Foot Ankle Int 2005;26(1):46-63. https://doi.org/10.1177/107110070502600109

Wukich DK, Mallory BR, Suder NC, Rosario BL. Tibiotalocalcaneal arthrodesis using retrograde intramedullary nail fixation: Comparison of patients with and without diabetes mellitus. J Foot Ankle Surg 2015;54(5):876-82. https://doi.org/10.1053/j.jfas.2015.02.019

Griffin MJ, Coughlin MJ. Evaluation of midterm results of the Panta Nail: An active compression tibiotalocalcaneal arthrodesis device. J Foot Ankle Surg 2018;57(1):74-80. Disponible en:

https://linkinghub.elsevier.com/retrieve/pii/S1067251617304982

Caravaggi CMF, Sganzaroli AB, Galenda P, Balaudo M, Gherardi P, Simonetti D, et al. Long-term follow-up of tibiocalcaneal arthrodesis in diabetic patients with early chronic Charcot osteoarthropathy. J Foot Ankle Surg 2012;51(4):408-11. https://doi.org/10.1053/j.jfas.2012.04.007

Caravaggi C, Cimmino M, Caruso S, Dalla Noce S. Intramedullary compressive nail fixation for the treatment of severe Charcot deformity of the ankle and rear foot. J Foot Ankle Surg 2006;45(1):20-4.

https://doi.org/10.1053/j.jfas.2005.10.003

DeVries JG, Berlet GC, Hyer CF. A retrospective comparative analysis of Charcot ankle stabilization using an intramedullary rod with or without application of circular external fixator--utilization of the Retrograde Arthrodesis Intramedullary Nail database. J Foot Ankle Surg 2012;51(4):420-5. https://doi.org/10.1053/j.jfas.2012.03.005

Ettinger S, Plaass C, Claassen L, Stukenborg-Colsman C, Yao D, Daniilidis K. Surgical management of

Charcot deformity for the foot and ankle-radiologic outcome after internal/external fixation. J Foot Ankle Surg 2016;55(3):522-8. https://doi.org/10.1053/j.jfas.2015.12.008

Myers TG, Lowery NJ, Frykberg RG, Wukich DK. Ankle and hindfoot fusions: comparison of outcomes in patients with and without diabetes. Foot Ankle Int 2012;33(1):20-8. https://doi.org/10.3113/FAI.2012.0020

Wukich DK, Lowery NJ, McMillen RL, Frykberg RG. Postoperative infection rates in foot and ankle surgery: a comparison of patients with and without diabetes mellitus. J Bone Joint Surg Am 2010;92(2):287-95. https://doi.org/10.2106/JBJS.I.00080

Richman J, Cota A, Weinfeld S. Intramedullary nailing and external ring fixation for tibiotalocalcaneal arthrodesis in Charcot arthropathy. Foot Ankle Int 2017;38(2):149-52. https://doi.org/10.1177/1071100716671884

Regauer M, Grasegger V, Fürmetz J, Kussmaul AC, Böcker W, Ehrnthaller C. High rate of complications after corrective midfoot/subtalar arthrodesis and Achilles tendon lengthening in Charcot arthropathy type Sanders 2 and 3. Int Orthop 2023;47(1):141-50. https://doi.org/10.1007/s00264-022-05567-y

Raspovic KM, Liu GT, Lalli T, Van Pelt M, Wukich DK. Optimizing results in diabetic Charcot reconstruction. Clin Podiatr Med Surg 2019;36(3):469-81. https://doi.org/10.1016/j.cpm.2019.02.010

Lee M, Choi WJ, Han SH, Jang J, Lee JW. Uncontrolled diabetes as a potential risk factor in tibiotalocalcaneal fusion using a retrograde intramedullary nail. Foot Ankle Surg 2018;24(6):542-8.

https://doi.org/10.1016/j.fas.2017.07.006

Akiboye F, Rayman G. Management of hyperglycemia and diabetes in orthopedic surgery. Curr Diab Rep 2017;17(2):13. https://doi.org/10.1007/s11892-017-0839-6

Cancienne JM, Cooper MT, Laroche KA, Verheul DW, Werner BC. Hemoglobin A as a predictor of postoperative infection following elective forefoot surgery. Foot Ankle Int 2017;38(8):832-7.

https://doi.org/10.1177/1071100717705140

Li S, Zhang J, Zheng H, Wang X, Liu Z, Sun T. Prognostic role of serum albumin, total lymphocyte count, and mini nutritional assessment on outcomes after geriatric hip fracture surgery: A meta-analysis and systematic review. J Arthroplasty 2019;34(6):1287-96. https://doi.org/10.1016/j.arth.2019.02.003

Pinzur MS, Stuck RM, Sage R, Hunt N, Rabinovich Z. Syme ankle disarticulation in patients with diabetes. J Bone Joint Surg Am 2003;85(9):1667-72. https://doi.org/10.2106/00004623-200309000-00003

Wukich DK, Frykberg RG, Kavarthapu V. Charcot neuroarthropathy in persons with diabetes: It’s time for a paradigm shift in our thinking. Diabetes Metab Res Rev 2024;40(3):e3754. https://doi.org/10.1002/dmrr.3754

Published
2025-06-27
How to Cite
Parise, A. C., Cafruni, V. M., Carrasco, N. M., Parma, J. M., Brué, J., Villena, D. S., Conti, L. Ángel, Sotelano, P., & Santini Araujo, M. G. (2025). Tibiotalocalcaneal Arthrodesis with Retrograde Intramedullary Nail in Patients with Charcot Neuroarthropathy of the Ankle and Hindfoot. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 90(3), 209-218. https://doi.org/10.15417/issn.1852-7434.2025.90.3.2117
Section
Clinical Research

Most read articles by the same author(s)