Alendronate-impregnated bone allograft integration. Experimental study

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Published: Oct 28, 2014
DOI: https://doi.org/10.15417/374
Keywords:
Alendronate, Allograft, Osteointegration, Bisphosphonates

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Luis S. Ruchelli
Christian A. Allende
Pablo A. Bruno
Natalia Gutiérrez
Jorge O. Flores
Ignacio Fernández Savoy

Abstract

Background: the use of allografts in bone reconstruction may be associated with an increased absorption of the latter, which may cause loss of stability and failure of reconstructions. The purpose of this experimental study was to investigate the variability in bone resorption in alendronate-impregnated allografts versus non-impregnated allografts.Methods: eighteen New Zealand rabbits were divided into two groups of nine animals each. We worked on the right femur; a bone window was performed and allografts were placed (with alendronate in group I and without alendronate in group II). All rabbits were sacrificed at 10 weeks after the initial procedure. Femur was evaluated with pathology, frontal and lateral radiographs and computed tomography. Osteointegration, vascularization and bone quality were evaluated.Results: no deaths or infections were reported, with 18 rabbits up to final analysis. Histology showed better osteointegration in group I than group II (p = 0.003), with well-defined attachment between receptor bone tissue and low osteoclastic activity. In group II, we observed less osteointegration. Assessment of bone resorption with radiographs and computed tomography showed no statistically significant difference between both groups. Group I showed more osteointegration of the allograft (p = 0.577; not significant). Conclusions: results of this experimental study show that allografts impregnated with alendronate help to improve the osteointegration. Also, it is a safe way and it is not associated with local or systemic risks in rabbits, even with high doses of alendronate.  

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How to Cite
Ruchelli, L. S., Allende, C. A., Bruno, P. A., Gutiérrez, N., Flores, J. O., & Fernández Savoy, I. (2014). Alendronate-impregnated bone allograft integration. Experimental study. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 79(4), 243-249. https://doi.org/10.15417/374
Issue
Vol 79 No 4 (2014)
Section
Basic Research
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Author Biography

Luis S. Ruchelli

Medico residente de sanatorio allende cordoba argentina

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