Modified Frailty Index as a Predictor of Postoperative Complications in Surgery for Pyogenic Spinal Infections

Keywords: Pyogenic spondylodiscitis, spinal infections, frailty, modified frailty index

Abstract

Introduction: Pyogenic spinal infection is a potentially deadly and disabling condition with specific surgical indications. Its surgical management requires a precise risk-benefit assessment. Our objective was to evaluate the modified frailty index as a predictor of early postoperative complications in patients undergoing surgery for pyogenic spondylodiscitis. Materials and Methods: We conducted an observational, analytical, and retrospective study of patients who underwent surgery for pyogenic spondylodiscitis between 2022 and 2025. The association between the modified frailty index and the incidence of postoperative complications (classified according to Clavien-Dindo), as well as clinical, microbiological, and surgical variables, was analyzed. Results: Serious complications were recorded in 54.5% of patients, with a mortality rate of 13.6%. Bivariate analysis showed significant associations between serious complications and male sex, diabetes, cervical location, neurological deficit, and hypoalbuminemia. Although a modified frailty index ≥0.27 did not reach statistical significance as a categorical variable (p=0.082), its analysis as a continuous variable revealed a significantly higher value in the group with serious complications (p=0.006). Conclusion: Preoperative frailty, assessed by the modified frailty index as a continuous variable, was significantly associated with severe postoperative complications.

Downloads

Download data is not yet available.

Author Biographies

Guillermo Alejandro Ricciardi, Orthopedics and Traumatology Service, Hospital General de Agudos “Dr. Teodoro Álvarez”, Autonomous City of Buenos Aires, Argentina
Orthopedics and Traumatology Service, Hospital General de Agudos “Dr. Teodoro Álvarez”, Autonomous City of Buenos Aires, Argentina
Santiago Formaggin, Spine Team, Sanatorio Güemes, Autonomous City of Buenos Aires, Argentina
Spine Team, Sanatorio Güemes, Autonomous City of Buenos Aires, Argentina
Ignacio Garfinkel, Spine Team, Sanatorio Güemes, Autonomous City of Buenos Aires, Argentina
Spine Team, Sanatorio Güemes, Autonomous City of Buenos Aires, Argentina
Gabriel Carrioli, Spine Team, Sanatorio Güemes, Autonomous City of Buenos Aires, Argentina
Spine Team, Sanatorio Güemes, Autonomous City of Buenos Aires, Argentina
Daniel Ricciardi, Spine Team, Sanatorio Güemes, Autonomous City of Buenos Aires, Argentina
Spine Team, Sanatorio Güemes, Autonomous City of Buenos Aires, Argentina

References

Boody BS, Tarazona DA, Vaccaro AR. Evaluation and management of pyogenic and tubercular spine infections.

Curr Rev Musculoskelet Med 2018;11(4):643-52. https://doi.org/10.1007/s12178-018-9523-y

Duarte RM, Vaccaro AR. Spinal infection: state of the art and management algorithm. Eur Spine J 2013;22(12):2787-99. https://doi.org/10.1007/s00586-013-2850-1

Rutges JP, Kempen DH, van Dijk M, Oner FC. Outcome of conservative and surgical treatment of pyogenic spondylodiscitis: a systematic literature review. Eur Spine J 2016;25(4):983-99. https://doi.org/10.1007/s00586-015-4318-y

Taylor DG, Buchholz AL, Sure DR, Buell TJ, Nguyen JH, Chen CJ, et al. Presentation and outcomes after medical and surgical treatment versus medical treatment alone of spontaneous infectious spondylodiscitis: a systematic literature review and meta-analysis. Global Spine J 2018;8(4 Suppl):49S-58S. https://doi.org/10.1177/2192568218799058

Blecher R, Frieler S, Qutteineh B, Pierre CA, Yilmaz E, Ishak B, et al. Who needs surgical stabilization for pyogenic spondylodiscitis? Retrospective analysis of non-surgically treated patients. Global Spine J 2023;13(6):1550-7. https://doi.org/10.1177/21925682211039498

Babic M, Simpfendorfer CS. Infections of the spine. Infect Dis Clin North Am 2017;31(2):279-97. https://doi.org/10.1016/j.idc.2017.01.003

Guerado E, Cerván AM. Surgical treatment of spondylodiscitis: an update. Int Orthop 2012;36(2):413-20. https://doi.org/10.1007/s00264-011-1441-1

Moskven E, Charest-Morin R, Flexman AM, Street JT. The measurements of frailty and their possible application to spinal conditions: a systematic review. Spine J 2022;22(9):1451-71. https://doi.org/10.1016/j.spinee.2022.03.010

Velanovich V, Antoine H, Swartz A, Peters D, Rubinfeld I. Accumulating deficits model of frailty and postoperative mortality and morbidity: its application to a national database. J Surg Res 2013;183(1):104-10. https://doi.org/10.1016/j.jss.2013.01.021

Kweh BTS, Lee HQ, Tan T, Tew KS, Leong R, Fitzgerald M, et al. Risk stratification of elderly patients undergoing spinal surgery using the modified frailty index. Global Spine J 2023;13(2):457-65. https://doi.org/10.1177/21925682221094053

Matsuo T, Kanda Y, Sakai Y, Yurube T, Takeoka Y, Miyazaki K, et al. Modified frailty index as a novel predictor for the incidence and severity of postoperative complications after spinal metastases surgery. Bone Joint J 2024;106-B(12):1469-76. https://doi.org/10.1302/0301-620X.106B12.BJJ-2024-0100.R1

Xu ZY, Hao XY, Wu D, Song QY, Wang XX. Prognostic value of 11-factor modified frailty index in postoperative adverse outcomes of elderly gastric cancer patients in China. World J Gastrointest Surg 2023;15(6):1093-103. https://doi.org/10.4240/wjgs.v15.i6.1093

Vettivel J, Bortz C, Passias PG, Baker JF. Pyogenic vertebral column osteomyelitis in adults: analysis of risk factors for 30-day and 1-year mortality in a single-center cohort study. Asian Spine J 2019;13(4):608-14. https://doi.org/10.31616/asj.2018.0295

Berbari EF, Kanj SS, Kowalski TJ, Darouiche RO, Widmer AF, Schmitt SK, et al. 2015 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults. Clin Infect Dis 2015;61(6):e26-46. https://doi.org/10.1093/cid/civ482.

Pola E, Autore G, Formica VM, Pambianco V, Colangelo D, Cauda R, et al. New classification for the treatment of pyogenic spondylodiscitis: validation study on a population of 250 patients with a 2-year follow-up. Eur Spine J 2017;26(Suppl 4):479-88. https://doi.org/10.1007/s00586-017-5043-5

Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004;240(2):205-13. https://doi.org/10.1097/01.sla.0000133083.54934.ae

Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40(5):373-83. https://doi.org/10.1016/0021-9681(87)90171-8

Mayhew D, Mendonca V, Murthy BVS. A review of ASA physical status: historical perspectives and modern developments. Anaesthesia 2019;74(3):373-9. https://doi.org/10.1111/anae.14569

Rawall S, Hiatt LA, Rajaram SM, Theiss S. Management of pyogenic spondylodiscitis in adults. J Am Acad Orthop Surg 2025;33(22):1257-64. https://doi.org/10.5435/JAAOS-D-24-01088

Ukon Y, Takenaka S, Makino T, Kashii M, Iwasaki M, Sakai Y, et al. Preoperative risk factors affecting outcome in surgically treated pyogenic spondylodiscitis. Global Spine J 2023;13(8):2201-9. https://doi.org/10.1177/21925682221077918

Ukon Y, Takenaka S, Hirai H, Sugiura T, Sakai Y, Fujimori T, et al. Establishment of scoring to predict severe complication after pyogenic spondylodiscitis surgery. Clin Spine Surg 2025;38(8):353-9. https://doi.org/10.1097/BSD.0000000000001756

Pola E, Taccari F, Autore G, Giovannenze F, Pambianco V, Cauda R, et al. Multidisciplinary management of pyogenic spondylodiscitis: epidemiological and clinical features, prognostic factors and long-term outcomes in 207 patients. Eur Spine J 2018;27(Suppl 2):229-36. https://doi.org/10.1007/s00586-018-5598-9

Camino-Willhuber G, Franklin A, Rosecrance K, Oyadomari S, Chan J, Holc F, et al. Preoperative hypoalbuminemia and dialysis increase morbidity/mortality after spine surgery for primary pyogenic spinal infections (ACS-NSQIP study). Surg Neurol Int. 2022;13:193. https://doi.org/10.25259/SNI_330_2022

Gamada H, Funayama T, Ogata Y, Setojima Y, Nakagawa T, Sunami T, et al. Challenges and limitations of the existing scoring systems for postoperative outcomes in thoracolumbar pyogenic spondylitis: a multicenter retrospective cohort study. Eur Spine J 2025;34(10):4717-27. https://doi.org/10.1007/s00586-025-08933-7

Bazán PL, Godoy Adaro AO, Padini E, Casco EA, Maruñak M. Aspectos morfológicos del absceso epidural espinal piógeno. Rev Asoc Argent Ortop Traumatol 2023;88(2):148-55.https://doi.org/10.15417/issn.1852-7434.2023.88.2.1513ID

Youn MS, Shin JK, Goh TS, Lee JS. Minimally invasive percutaneous endoscopic treatment for acute pyogenic spondylodiscitis following vertebroplasty. Eur Spine J 2018;27(Suppl 3):458-64. https://doi.org/10.1007/s00586-018-5478-3

Tong YJ, Liu JH, Fan SW, Zhao FD. One-stage debridement via oblique lateral interbody fusion corridor combined with posterior pedicle screw fixation in treating spontaneous lumbar infectious spondylodiscitis: a case series. Orthop Surg 2019;11(6):1109-19. https://doi.org/10.1111/os.12562

Madhavan K, Vanni S, Williams SK. Direct lateral retroperitoneal approach for the surgical treatment of lumbar discitis and osteomyelitis. Neurosurg Focus 2014;37(2):E5. https://doi.org/10.3171/2014.6.FOCUS14150

Published
2026-04-30
How to Cite
Ricciardi, G. A., Formaggin, S., Garfinkel, I., Carrioli, G., & Ricciardi, D. (2026). Modified Frailty Index as a Predictor of Postoperative Complications in Surgery for Pyogenic Spinal Infections. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 91(2), 138-150. https://doi.org/10.15417/issn.1852-7434.2026.91.2.2232
Section
Clinical Research